Pleiotropy drives evolutionary repair of the responsiveness of polarized cell growth to environmental cues

The ability of cells to translate different extracellular cues into intracellular responses is vital for their survival in unpredictable environments. In Saccharomyces cerevisiae , cell polarity modulated response environmental signals which allows adopt varying morphologies external conditions. responsiveness depends on the integration molecular network that regulates establishment with networks signal changes. coupling often leads pleiotropic interactions can make it difficult determine whether respond emerges as an evolutionary challenges or a result between traits. Here, we study how propensity S. evolve toward state responsive complexity environment. We show deletion two genes, BEM3 and NRP1 disrupts onset diauxic shift. By combining experimental evolution whole-genome sequencing, find restoration these correlates mutations genes involved sphingolipid synthesis pathway frequently settle evolving populations irrespective selective conclude significant contribution are cues.